skinsafecheck Ingredient Checker

Fungal acne ingredient checker

Fungal acne is Malassezia folliculitis: an overgrowth of Malassezia yeast in the hair follicles (Rubenstein and Malerich, 2014). The yeast cannot make its own fatty acids, so it lives on the fats around it. Paste a product's ingredient list and this checker marks the ingredients that fall in the four classes lab studies found it can feed on.

It gives no safe or unsafe verdict, because the research does not support one. What a match means, and what it does not, is set out further down.

This tool reads ingredient names against four rules drawn from published lab studies of Malassezia. It does not test the product and it cannot diagnose fungal acne. A match is a class of ingredient, and no match is not a clean bill of health.

The four rules

Each rule is a class of chemistry, and each one comes from a study you can read. Most of them were done on yeast grown in a dish.

Lab studies found Malassezia could use each of these classes as food. Species differ, and none of this was tested on people's skin.

Rule 1. Fatty acid, C12 to C24

Malassezia has no gene for fatty acid synthase, so it cannot build fatty acids and has to take them from outside. That was found in the genome of M. globosa (Xu and colleagues, 2007) and then in all 14 species (Wu and colleagues, 2015). In the study the range comes from, the yeast grew only when fatty acids from C12 to C24 were added, and every acid tested in that range supported growth except elaidic and nervonic acid (Porro and colleagues, 1976).

Matches lauric, myristic, palmitic, stearic, oleic, linoleic and the other named acids from C12 to C24, and their salts. Evidence: genome studies and one in vitro growth study.

Rule 2. Ester of a C12 to C24 fatty acid

M. furfur split the fatty acid esters it was given and grew on the acids released. How well it did depended on the alcohol half of the ester: ethyl esters were split best, then isopropyl, and decyl oleate only a little (Mayser and colleagues, 1995). A later test of ten emulsifiers found every strain grew on PEG-7 glyceryl cocoate, PEG glyceryl stearate and macrogol-50 stearate, while PEG-35 castor oil was used only by M. furfur (Mayser and colleagues, 1997).

Matches names such as isopropyl myristate, glyceryl stearate, PEG-100 stearate, cetyl palmitate and sorbitan oleate, plus jojoba, which is a liquid wax made of long-chain esters. Evidence: in vitro.

Rule 3. Polysorbate

Polysorbates 20, 40, 60 and 80 are sold as Tween, and labs use them as a lipid source to tell the species apart (Guého and colleagues, 1996). That is also why this rule is the weakest of the four. In one identification study, M. furfur used all four, while M. globosa and M. restricta, two of the species the authors call clinically important, used none of them as their only lipid (Kaneko and colleagues, 2007).

Matches polysorbate 20, 40, 60, 80 and their close variants. Evidence: in vitro, varies by species.

Rule 4. Plant or animal oil or butter

Plant and animal oils and butters are mostly triglycerides. Malassezia makes lipases that split triglycerides into free fatty acids (Ro and Dawson, 2005), and whole M. globosa cells split both diolein and triolein (DeAngelis and colleagues, 2007). Grown under olive oil, M. sympodialis and the other newer species released large amounts of free fatty acids from it (Mayser and colleagues, 1998).

Matches seed, kernel, nut and fruit oils, butters and triglycerides. It leaves out mineral oil, silicones and essential oils, which are not triglycerides. Evidence: a review, in vitro work and human scalp samples.

Where the checker applies no rule, and why

Medium chain, C8 to C10

Caprylic and capric acid, and caprylic/capric triglyceride, sit below the C12 to C24 range. In lab studies medium-chain triglycerides and medium-chain fatty acids suppressed M. furfur and M. sympodialis (Papavassilis and colleagues, 1999), and glyceryl monocaprylate, a C8 ester, had the lowest inhibitory concentration of the esters tested on M. pachydermatis (Koch and colleagues, 2022).

Undecylenic acid, C11

Some online lists start their range at C11. The growth study behind the range starts at C12, and undecylenic acid (C11) released from its esters was antifungal in the lab (Koch and colleagues, 2020), so this checker starts at C12.

Ferments

We found no peer-reviewed study showing that ferments such as galactomyces feed Malassezia. One small human trial found a Saccharomyces and Lactobacillus ferment complex lowered Malassezia on sensitive scalps over 28 days (Wang and colleagues, 2023). One trial settles nothing, and ferment filtrates differ by product, so the checker applies no rule either way.

Fatty alcohol or ethers

Cetyl, stearyl and cetearyl alcohol, and ethers such as laureth and ceteareth, were not tested in any study behind these rules. The checker says so rather than guess.

What the evidence shows, and what it does not

  • Almost all of it is lab work. The rules come from yeast grown in dishes and from genome studies. They show what Malassezia can use as food. They do not show what happens when a product sits on a person's skin.
  • Species behave differently. A class one species grows on, another may not use at all, as the polysorbate results show.
  • Skin already feeds it. Sebum is itself made of triglycerides and fatty acids, which Malassezia breaks down (Ro and Dawson, 2005), so a product is one source of food among several.
  • No study tests avoidance. We found no trial of whether avoiding these ingredients prevents or clears Malassezia folliculitis, and no case report of a cosmetic causing it.
  • What clinicians name as risks. A 1985 series of 51 patients named occlusion and greasy skin as probable predisposing factors (Bäck and colleagues, 1985). Diagnosis and treatment belong with a doctor, and the European dermatology position statement sets out how it is done (Henning and colleagues, 2023).
  • The checker reads names only. It does not know how much of an ingredient a product holds, or how the formula behaves as a whole.

Checking for pore-clogging ingredients is a different question with a different body of research. The comedogenic ingredient checker answers that one.

Common questions

What is fungal acne?
Fungal acne is the everyday name for Malassezia folliculitis, an overgrowth of Malassezia yeast from the normal skin flora in the hair follicles. It usually shows as small bumps and pustules of the same size, often on the chest, back, upper arms and face. It is often mistaken for ordinary acne and can persist for years on typical acne treatment, so it needs a diagnosis from a doctor.
Does no match mean a product is fine for fungal acne?
No. It means none of the four rules on this page covers the names you pasted. The rules come from lab studies of what Malassezia can feed on, and no study has tested whether avoiding these ingredients prevents or clears fungal acne in people.
Why are ferments not flagged?
Some online lists flag ferments such as galactomyces. We found no peer-reviewed study showing that ferments feed Malassezia, and one small human trial in 2023 found a Saccharomyces and Lactobacillus ferment complex lowered Malassezia on the scalp. With no evidence to cite, the checker applies no rule.
Why is caprylic/capric triglyceride not flagged?
Caprylic and capric acid have 8 and 10 carbons, below the C12 to C24 range the yeast grew on. In lab studies, medium-chain triglycerides and C8 esters slowed or stopped Malassezia growth, so no feeding rule applies to them.

Studies behind the rules

  1. Porro MN, Passi S, Caprilli F, Nazzaro P, Morpurgo G. “Growth requirements and lipid metabolism of Pityrosporum orbiculare.” Journal of Investigative Dermatology, March 1976;66(3):178–182. (opens in a new tab) In vitro. The yeast grew only when fatty acids from the C12 to C24 series were added; every saturated and unsaturated acid tested supported growth except elaidic and nervonic acid.
  2. Xu J, Saunders CW, Hu P, et al. “Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.” PNAS, November 2007;104(47):18730–18735. (opens in a new tab) Genome study. M. globosa has no fatty acid synthase gene, which explains why it needs lipids from outside, and it carries several secreted lipases.
  3. Wu G, Zhao H, Li C, et al. “Genus-wide comparative genomics of Malassezia delineates its phylogeny, physiology, and niche adaptation on human skin.” PLoS Genetics, November 2015;11(11):e1005614. (opens in a new tab) Genomes of all 14 accepted species: the fatty acid synthase gene is missing in every one. Several authors work for a maker of anti-dandruff shampoo, which the paper declares.
  4. Mayser P, Führer D, Schmidt R, Gründer K. “Hydrolysis of fatty acid esters by Malassezia furfur: different utilization depending on alcohol moiety.” Acta Dermato-Venereologica, March 1995;75(2):105–109. (opens in a new tab) In vitro. M. furfur split the fatty acid esters tested and grew on the released acids. Ethyl esters were split best, then isopropyl esters; decyl oleate only a little.
  5. Mayser P, Haze P, Papavassilis C, Pickel M, Gruender K, Guého E. “Differentiation of Malassezia species: selectivity of cremophor EL, castor oil and ricinoleic acid for M. furfur.” British Journal of Dermatology, August 1997;137(2):208–213. (opens in a new tab) In vitro, ten emulsifiers. Every strain grew on PEG-7 glyceryl cocoate, PEG glyceryl stearate and macrogol-50 stearate; PEG-35 castor oil was used only by M. furfur.
  6. Guého E, Midgley G, Guillot J. “The genus Malassezia with description of four new species.” Antonie van Leeuwenhoek, May 1996;69(4):337–355. (opens in a new tab) The species descriptions, including whether each can use Tween 20, 40, 60 and 80 as its lipid source.
  7. Kaneko T, Makimura K, Abe M, et al. “Revised culture-based system for identification of Malassezia species.” Journal of Clinical Microbiology, November 2007;45(11):3737–3742. (opens in a new tab) In vitro. M. furfur used all four Tweens; M. globosa and M. restricta, two species the authors call clinically important, used none of them as a sole lipid source. Atypical strains were also seen.
  8. Ro BI, Dawson TL. “The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff.” Journal of Investigative Dermatology Symposium Proceedings, December 2005;10(3):194–197. (opens in a new tab) Review. M. restricta and M. globosa free fatty acids from triglycerides, consume particular saturated ones and leave the unsaturated ones behind.
  9. DeAngelis YM, Saunders CW, Johnstone KR, et al. “Isolation and expression of a Malassezia globosa lipase gene, LIP1.” Journal of Investigative Dermatology, September 2007;127(9):2138–2146. (opens in a new tab) In vitro and scalp samples. Whole M. globosa cells split both diolein and triolein, and the lipase was expressed on human scalps.
  10. Mayser P, Pickel M, Haze P, et al. “Different utilization of neutral lipids by Malassezia furfur and Malassezia sympodialis.” Medical Mycology, February 1998;36(1):7–14. (opens in a new tab) In vitro, cultured under olive oil. M. sympodialis and the other newer species released large amounts of free fatty acids from the oil.
  11. Papavassilis C, Mach KK, Mayser PA. “Medium-chain triglycerides inhibit growth of Malassezia: implications for prevention of systemic infection.” Critical Care Medicine, September 1999;27(9):1781–1786. (opens in a new tab) In vitro. Medium-chain triglycerides and medium-chain free fatty acids suppressed M. furfur and M. sympodialis.
  12. Koch C, Nordzieke S, Grieger J, Mayser P. “Medium-chain fatty acid esters are effective even in azole-resistant Malassezia pachydermatis.” Mycoses, December 2022;65(12):1188–1193. (opens in a new tab) In vitro, 17 strains of M. pachydermatis. Glyceryl monocaprylate (C8) and 3-hydroxypropyl caprylate had the lowest inhibitory concentration of the esters tested.
  13. Koch C, Pesaro M, Schmaus G, Mayser P. “Medium-chain fatty acid esters: optimising their efficacy as anti-Malassezia agents.” Mycoses, July 2020;63(7):704–710. (opens in a new tab) In vitro. Malassezia split octanoic (C8) and undecylenic (C11) monoesters, and the acids released were antifungal.
  14. Wang Y, et al. “Effects of a postbiotic Saccharomyces and Lactobacillus ferment complex on the scalp microbiome of Chinese women with sensitive scalp syndrome.” Clinical, Cosmetic and Investigational Dermatology, 2023;16:2623–2635. (opens in a new tab) A small human trial. The ferment complex, used for 28 days, lowered Malassezia on sensitive scalps.
  15. Bäck O, Faergemann J, Hörnqvist R. “Pityrosporum folliculitis: a common disease of the young and middle-aged.” Journal of the American Academy of Dermatology, January 1985;12(1 Pt 1):56–61. (opens in a new tab) A case series of 51 patients. Names occlusion and greasy skin as probable predisposing factors.
  16. Rubenstein RM, Malerich SA. “Malassezia (pityrosporum) folliculitis.” Journal of Clinical and Aesthetic Dermatology, March 2014;7(3):37–41. (opens in a new tab) A review of how the condition presents and how it is diagnosed and treated.
  17. Henning MAS, et al. “Position statement: recommendations on the diagnosis and treatment of Malassezia folliculitis.” Journal of the European Academy of Dermatology and Venereology, July 2023;37(7):1268–1275. (opens in a new tab) The European Academy of Dermatology and Venereology position on diagnosing and treating it.